Cellibre
Enzyme Engineering. Reimagined
When Cellibre - a company revolutionizing agriculture manufacturing – came to Codex DNA asking how to shorten their complex Design-Build-Test process, we listened.
WATCH VIDEO: Cellibre’s protein engineering lead describes how Codex DNA’s technology and expertise empowered their team to rethink their enzyme engineering process
"With the ability to make any design I want; it allows me the freedom to explore these complex designs. Codex DNA solutions have really improved our throughput, both in the time to make the libraries and to speed the engineering cycles."
Russell Komor
Director, protein engineering and biochemistry at Cellibre
Using Rapid Design-Build-Test Cycles to Transform Legacy Supply Chains via Biomanufacturing
- Unique de novo modular library design enabled rapid generation of high-diversity and low diversity libraries
- Targeted libraries identified every sequence, what worked and what didn’t to accurately refine AI-based algorithm
- High sequence fidelity enabled elimination of tedious verification steps
- Continued iteration helped Identify enzymes with 10,000X higher activity than the original enzyme.
WATCH VIDEO: Cellibre CEO Ben Chiarelli discusses how the partnership with Codex DNA is enabling them to accelerate enzyme discovery and advance their mission of unlocking natural products across a variety of industries
High-fidelity library synthesis with the BioXp™ 3250 platform
- Bypass conventional bacterial techniques that are expensive and time consuming
- Build up to 32 high-fidelity custom constructs in a single overnight run
- Test many iterations of library designs in a short amount of time
Case study
How Codex DNA helped Cellibre optimize their enzyme engineering process
In this case study, you’ll find out:
- How Cellibre used Codex DNA’s rapid DNA synthesis platform to accelerate iteration for enzyme engineering
- How Codex DNA solutions produced a series of targeted libraries to shorten the design, build, test process
- The automated BioXp system behind the multiple rounds of engineering
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