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Genome engineering

Engineer large, complex, fully-synthetic genomes

Genome Engineering or Editing: It’s no longer how, but what, to build

The process of changing an organism’s original molecular code is called genome engineering or genome editing. The term editing has gained more popularity over the last few years with the discovery of CRISPR molecules that power genome engineering processes with more precision.

DNA synthesis is a fundamental tool in genome engineering, whether you are engineering an existing genome or building one from scratch. Traditional molecular cloning and gene editing steps are tedious, manual in nature and require cellular transformation, which can take three to four weeks. In addition to being time-consuming, classic genome engineering and DNA assembly techniques are limited in the size and complexity of constructs that can be engineered.

Scientists are no longer willing to wait weeks or sometimes months for sequence builds. The ability to quickly make large and complex error-free DNA molecules comprising entire gene sequences is what separates Codex DNA from the rest.

Genome research

Removing limitations with hands-free overnight synthesis

The BioXp™ system enables rapid synthesis within days to weeks, as well as the ability to modify large constructs and full-length genomes.

The BioXp™ system provides an automated workflow solution enabling users to:

  • Engineer genomes and vaccine scaffolds that were previously inaccessible due to size, complexity, and resource limitations
  • Engineer fully synthetic genomes lacking pathogenicity through rational redesign
  • Rapidly pursue research and development of emerging strains or modify existing genomic constructs based on experimental results
Submit sequence through secure myBioXperience portal

Submit sequence through secure myBioXperience™ portal

Receive and load BioXp kits on the BioXp system

Receive and load BioXp kits™ on the BioXp system

Press start

Press start

Automated synthetic biology solutions

Through the power of Gibson Assembly® and the 2-step error correction BioXp technology, Codex DNA enables push-button, automated building of synthetic DNA.

In a single run, researchers can construct genes, large clones, or variant DNA libraries – drastically reducing build time and improving productivity.

No need to wait weeks, get hi-fidelity DNA constructs overnight.

DNA Variant Libraries

Build scanning, site-saturation, combinatorial, and targeted DNA variant libraries using IUPAC nucleotides to optimize protein binding and function.

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Cloning

Build long error-corrected, de novo synthetic genes up to 7.2kb in length, and clone them into customer specified vectors.

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Gene Fragment Synthesis

Build error-corrected, de novo synthetic genes up to 1.8kb in length.

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DNA Amplification

Amplify up to 10 micrograms of error-corrected genes cloned into either a made-to-stock or customer vectors.

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Contact us

The expertise of our scientists, engineers and supporting teams are at your service! Submit the form below and/or call us at 858.526.3080.

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