It can be tough to keep up on the latest COVID-19 news, but a new ebook from Biocompare is here to help. The ebook offers a nice array of articles focused on how novel tools are being used to accelerate pandemic-related research.
The Codex DNA team had the great opportunity to contribute an article to this new resource (see page 28 of the ebook). In it, we offer a look at how the BioXp™ system is being used to combat COVID-19 by accelerating the discovery of much-needed vaccines, diagnostics, and therapeutics.
The article includes a look at the basic biology of SARS-CoV-2, which shares about 80% of its genomic identity with the original SARS virus that broke out in the human population in 2002. It also describes how understanding its genomic content has made a difference in the current pandemic. “Rationally redesigned, full-length, attenuated genomes help develop vaccines against the virus,” our team writes. “Additionally, viral genome parts facilitate raising antibodies against viral antigens, enabling the development of therapeutic options that could effectively treat infected patients.”
Early in the pandemic, Codex DNA synthesized and released the full SARS-CoV-2 genome. Since then, we have released several more synthetic genomes, for this virus, to empower researchers around the world in the race to conquer the pathogen.
The article gives an in-depth look at how we approached those synthesis projects, such as the hierarchical assembly process we used, our proprietary design tools, and results of the sequencing analysis we performed to test our final product. That first synthetic genome — created without some key technical advances that made subsequent genomes much easier to build — represented an extraordinary effort from our scientists. We’re eager to show the life sciences community how it came together, and how it can be used beyond COVID-19.
“With the ability to synthesize highly accurate dsDNA molecules and enable rapid iteration cycles of design-build-test, the BioXp™ system will extend the discovery capabilities of researchers against other infectious agents of humans, livestock, and plants,” the article concludes.
We also highly recommend the rest of the content in Biocompare’s ebook. You’ll find helpful information on topics such as immunoassay development, how scientists hunt for neutralizing inhibitors to SARS-CoV-2, how automation can help overcome pandemic-associated resource shortages, and more.
Download the full ebook by filling out this quick form.